From New York and North Jersey:

Follow the Garden State Parkway to mile Zero. At the end bear left on Route 109 over the bridge and into Cape May City. As you cross the small bridge with boats on either side, stay to the right on Lafayette Street. At the second light in town, turn left onto Ocean Street. Go 3 blocks to the corner of Ocean and Columbia Ave. On the left, at 29 Ocean Street, you will see The Humphrey Hughes House. From Within Cape May - Map

From Philadelphia and West:

Follow Interstate 76 East and cross the Walt Whitman Bridge. Stay on Route 42 towards Atlantic City. Bear right on Route 55 South. After 40 minutes this will put you on Route 47 south, then 347 south and back to 47 south. Follow 47 south to the Garden State Parkway south.

Follow the Garden State Parkway to mile Zero. At the end bear left on Route 109 over the bridge and into Cape May City. As you cross the small bridge with boats on either side, stay to the right on Lafayette Street. At the second light in town, turn left onto Ocean Street. Go 3 blocks to the corner of Ocean and Columbia Ave. On the left, at 29 Ocean Street, you will see The Humphrey Hughes House. From Within Cape May - Map

From Lancaster area, you may want to use the Commodore Barry Bridge and follow Route 322 east to Route 55 south.

From Baltimore and Washington:

Follow Interstate 95 North towards Wilmington. Below Wilmington follow signs to the Delaware Memorial Bridge and the New Jersey Turnpike. Just after crossing the bridge, follow Route 40 east towards Atlantic City. After the town of Elmer, watch for Route 55 south.

Take Route 55 South. After 40 minutes this will put you on Route 47 south, then 347 south and back to 47 south. Follow 47 south to the Garden State Parkway south.

Follow the Garden State Parkway to mile Zero. At the end bear left on Route 109 over the bridge and into Cape May City. As you cross the small bridge with boats on either side, stay to the right on Lafayette Street. At the second light in town, turn left onto Ocean Street. Go 3 blocks to the corner of Ocean and Columbia Ave. On the left, at 29 Ocean Street, you will see The Humphrey Hughes House. From Within Cape May - Map

From Washington and Points South:

You may want to consider the Cape May Lewes Ferry. From the Washington beltway (495), take Route 50 east across the Chesapeake Bay Bridge. In the Wye Mills area, take Route 404 east, Route 16 east, Route 1 south and follow signs to the Ferry Terminal in Lewes, Delaware. You can make reservations on the ferry ($5 extra) by calling 1-800-643-3779. It is an approximately 80 minute cruise across the bay. Cape May is about 15 minutes from the Ferry Terminal. From Within Cape May - Map

From Within Cape May: